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Structural and biochemical studies of virus : host interactions in HIV-1
(University of Missouri--Columbia, 2023)
[EMBARGOED UNTIL 8/1/2024] According to 2021 UNAIDS estimates, as of 2020, 680,000 people died from AIDS-related illnesses and 38 million people globally were living with Human Immunodeficiency Virus (HIV) (1). Despite ...
Structural and kinetic studies of proline metabolic enzyme inhibitors and inactivators
(University of Missouri--Columbia, 2021)
Structural and kinetic studies of the proline metabolic enzymes proline dehydrogenase (PRODH), [delta]1-pyrroline-5-carboxylate reductase (PYCR), and aldehyde dehydrogenase 4A1 (ALDH4A1) are presented in this thesis. ...
On the role of the purinergic receptor P2Y2R in oral cancer and salivary gland dysfunction
(University of Missouri--Columbia, 2023)
[EMBARGOED UNTIL 5/1/2024] Due to the important roles the oral cavity plays in our daily lives ranging from eating and drinking to speech, diseases of the oral cavity significantly impact the quality of life. Oral cancers ...
HIV-1 5'UTR RNA structures: connections to infectious lifecycle and potential therapeutic applications
(University of Missouri--Columbia, 2021)
Human immunodeficiency virus (HIV) is among the most sinister pathogens plaguing man. As of now, we do not yet have a method to "cure" infection once the virus has integrated into the host genome. It has the highest mutation ...
A transcriptomic approach to uncovering the molecular mechanisms of maize nodal root growth maintenance during drought stress in the field
(University of Missouri--Columbia, 2021)
Drought is the most important factor limiting crop production across the globe. Therefore, understanding how plants adapt and survive drought conditions is critical for improving food production with lower water input. One ...